The San Francisco 49ers have 53 jobs to give to 90 guys, or 91 if you account for the international pathway exception. These few days following their last preseason game and when final rosters are due on Sunday can get pretty complicated, but in a nutshell the 49ers can put two players on IR (injured reserve) and keep the two players they already have on PUP (physically unable to perform) without using any of the 53 active roster spots on Sunday, if they are OK with having those injured players
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